Supplementation With Grape Seed Extract May Benefit Patients With Nonalcoholic Fatty Liver Disease

Supplementation With Grape Seed Extract May Benefit Patients With Nonalcoholic Fatty Liver Disease

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Reference: “Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change,” Khoshbaten M, Najafipoor F, et al, Saudi J Gastroenterol, 2010; 16(3): 194-7. (Address: Department of Drug Applied Research Center, Tabriz University of Medical Sciences, Iran).

Summary: In a controlled study involving 30 patients with nonalcoholic fatty liver disease (NAFLD), results indicate that supplementation with grape seed extract may exert beneficial effects. The patients were randomized to grape seed extract or vitamin C (1000 mg / 12 hours) for 3 months. At intervention end, serum levels of ALT (alanine aminotransferase) decreased significantly in patients treated with GSE when compared to controls (vitamin C group). Additionally, grape seed extract supplementation significantly improved grade of steatosis. Thus, the authors conclude, “This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.”